If your skin has been feeling dull, dry, or less firm lately, you’re not alone. These changes are common as skin ages, and while they’re natural, many people seek gentle, effective ways to support skin health from within.
One treatment gaining attention recently is injectable skin boosters that work deeply to hydrate and strengthen the skin. Among them, polynucleotide (PN) boosters—especially those derived from salmon DNA—are notable for their ability to encourage skin regeneration.
What Are Polynucleotides, and Why are They important?
Polynucleotides are natural molecules extracted and purified from salmon DNA. Because they’re highly compatible with human skin and rarely cause irritation, they’ve become popular in skin regeneration treatments. Once injected, PN helps activate fibroblasts—the cells responsible for producing collagen and repairing skin tissue—leading to improvements in elasticity, hydration, and overall skin texture.
Unlike creams or serums that work only on the skin’s surface, PN treatments support the skin’s natural renewal from deeper layers, making them especially useful for addressing signs of aging, environmental damage, or tired skin.
SHEERGEN: A Next-Generation, Gentle PN Skin Booster from Korea
One of the newest PN treatments is SHEERGEN, developed in Korea. It contains 20 mg/ml of highly purified Polynucleotides in a clear, injectable hydrogel designed to absorb into both the epidermis and dermis layers. This helps stimulate collagen and elastin production gradually over time.
The treatment uses a very fine 32G needle, minimizing discomfort while delivering the product precisely where it’s needed. Each box comes with two pre-filled syringes for convenience.
Clinical Results After Just Two Weeks
In recent clinical observations, SHEERGEN showed measurable improvements in key skin health markers:
- Hydration increased by 16.69%
- Elasticity improved by 23.78%
- Skin density rose significantly (from 71.7 to 92.6)
- Elasticity (measured separately) improved from 63.45 to 84.22 (+33.0)
Participants also noticed smoother skin texture, brighter skin tone, and an overall fresher appearance.
Treatment Schedule and Longevity
For best results, a typical treatment plan includes:
- Initial phase: 3 sessions per month
- Maintenance phase: 2 sessions every 3 to 6 months
Results generally last between 6 to 12 months, and in many cases, can continue for over a year depending on skin condition and lifestyle.
In Summary
Polynucleotide skin boosters like SHEERGEN are gaining trust not because of hype, but due to their scientifically backed ability to support natural skin repair. They don’t promise instant miracles but offer steady, visible improvements in hydration, elasticity, and skin structure.
If you’ve been curious about PN treatments, SHEERGEN is a modern, practical option worth considering—combining clinical evidence with a gentle, effective formula for long-term skin health.

Angela Spearman is a journalist at EzineMark who enjoys writing about the latest trending technology and business news.